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Information on Diagnosis and Treatment of Endometrial Cancer















A note about the sources we use for education materials:

We believe in providing you with information that you can trust. That means we take everything into consideration: strong medical evidence and wisdom and knowledge from the community. We also lean on health care providers focused on Black women’s health to contribute.

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How was I diagnosed with Endometrial Cancer?  

You may have been experiencing symptoms that included unexplained bleeding, pain with intercourse, or something as common as severe cramping during your period. If you had not already been seeing your gynecologist annually, these symptoms may have alerted you to suspect something was wrong. While often times these symptoms could be a common occurrence for people who menstruate, they were not common or normal for you, and you notified your doctor. You have now taken the first step in getting in front of your diagnosis!!!

What now?

Once you meet with your doctor, they will have a plan for understanding the cause of your symptoms.

How will/did the doctor determine if I have Endometrial Cancer? 

The plan for understanding the cause of your symptoms, should include the following: 

Pelvic Exam: On your initial visit, you will likely have an internal pelvic examination where your Gynecologist can palpate or "feel" for any abnormalities. It is okay to have a pelvic examination even if you are bleeding at the time of your visit.

Ultrasound: The first test you may have had is an ultrasound on the outside of your pelvis or inside of your vagina. An ultrasound provides detailed picture of your reproductive parts. In most cases an ultrasound alone cannot "see" everything that is going on.

The only way to be sure that cancer is causing your symptoms is to get a sample of tissue from your endometrium, or the lining of the uterus. Doctors can do this with two different tests:

Biopsy: This procedure usually happens in a clinic or doctor's office.  It starts off like a Pap smear. The doctor uses a speculum to see into your cervix then place a small tube into your uterus to collect a sample of tissue.

Dilation and Curettage: This procedure typically happens in an operating room. The doctor uses small tools to open the entry to your cervix and can then take a larger sample of tissue from the inner lining of the uterus.

Whichever test the doctor uses or used, the tissue sample they take from your uterus will be examined to see if cells are growing abnormally, which is confirmation of cancer. Because this started in the uterus, it is called "Endometrial", "Uterine" or "Womb" cancer. 

What now?

It is important to know the stage and grade of your cancer so you and your care team can identify the treatment plan that will work best for you. 

How do I know what Stage and Grade of Endometrial Cancer I have?


The stage of the cancer refers to how far the cancer cells spread outside of the uterus. The process of tests are called "staging."

During surgery, your care team looked in your pelvic region to see if there were any cancer cells outside of your uterus. They may have also done additional imaging – such as an MRI or an CT scan - to look at detailed pictures of other organs to make sure there are no cancer cells in other places. 

The stages of this cancer are:

  • Stage 1: Cells found only inside the uterus.
  • Stage 2: Cells found to have spread to the cervix (opening of the uterus).
  • Stage 3: Cells found to have spread to lymph nodes or other areas in the pelvis or abdomen.   
  • Stage 4: Cells found to have spread to lungs or other organs. 


The grade of cancer is a scoring system to predict how fast the cancer might grow and if it is likely to spread. You might hear members of your care team describe grade as how “aggressive” the cancer is. A doctor will determine the grade by looking at the cancer cells from your biopsy, D&C, or your surgery under a microscope. 

The Grade of cancer comes in 3 ratings: 

  • Grade 1: Low Grade
  • Grade 2: Intermediate Grade
  • Grade 3: High Grade

Type or Histology

The type or histology of the cancer refers to which kinds of cancer cells are growing, and how the cells use the female hormone, estrogen. This helps your care team determine treatment options to present you with, and to identify the risk of the cancer spreading or coming back. Histology types include: Endometrioid, Serous or Papillary Serous, Carcinosarcoma, Mucinous, or Mixed.

What now?

Now it is time for treatment. During this time you will meet a group of healthcare providers that will help guide you through your treatment process. This group of providers is referred to as your care team. 

What is the treatment for Endometrial Cancer? 

There are a number of treatment options for Endometrial Cancer. Treatment options can include one or more of the following:


Surgery that removes your uterus, cervix, fallopian tubes, and ovaries – or a total hysterectomy - is the most common treatment for endometrial cancer.

Hysterectomy should be done in a minimally invasive way, with small incisions that allow for small instruments and a camera to enter your body (laparoscopy or robotic surgery). This allows for the full surgery you need and a speedy recovery. If you are not offered a minimally invasive surgery, there should be a specific reason for this that you understand. If you are not satisfied with the reason, seek a 2nd opinion (click HERE to hear Margie talk about her experience getting a second opinion.) The surgeon may also remove lymph nodes from other parts of your pelvis or abdomen to check if the cancer has spread to those areas.  


Radiation therapy uses x-rays or other types of radiation to kill cancer cells or stop them from growing. 

Radiation therapy may be suggested for before or after surgery.

Before surgery (also called neoadjuvant therapy): Your care team may recommend radiation treatment before surgery to help make the cancer smaller. After surgery (also called adjuvant therapy): Your care team may recommend radiation after surgery to kill any remaining cancer cells they weren’t able to remove, or those that have spread to other areas in the pelvis or abdomen. 

Radiation therapy may be external or internal.

External radiation: A machine directs radiation toward an area of your body. The procedure itself does not hurt. It only takes a few minutes each day at a clinic, hospital, or office, and is typically recommended every day for about 6 weeks.  Internal radiation (also called brachytherapy): A small capsule that holds radiation is placed inside your vagina. After the capsule is inserted, your care team may recommend that you remain at the hospital for monitoring (this makes it an inpatient procedure), or you may be able to go home (making it an outpatient procedure). 

Hormone Therapy

Some types of endometrial cancer – those with receptors for the female hormone, estrogen that are low grade – can be controlled by using hormones. This is primarily used in young people who wish to have children in the future or those in whom surgery will not be safe. In these cases, hormones taken in a pill or shot block receptors to keep the cancer cells from receiving the estrogen it would use to grow. 


Chemotherapy uses pharmaceutical drugs to kill cancer cells. It is usually given by injection into a vein. The drugs travel through your bloodstream. It targets cancer cells throughout the body, but also affects healthy cells. To keep the damage to healthy cells low, chemotherapy usually happens in cycles, alternating with rest periods. Cycles of chemotherapy typically begin in the months following surgery and usually occur in a hospital or doctor’s office. 

What are the goals of treatment?

Knowing what to expect from treatment is important so you, your care team and your caregivers can work together to make the best decisions possible for you. There are many questions that arise during treatment that you will want the answers to, this is understandable. Commonly you will want to know will you be cured of cancer? What are your chances of being cured? If there is no cure, will treatment help you live better or longer? While the answer to these questions may not be readily available, the goal(s) of treatment will be in line with the treatment options available to you and your stage and grade of cancer. Your care team will work closely with you so that you clearly understand goals identified specifically for you.

How do I know if treatment is working? 

Depending on the specifics of your cancer, there are multiple tests your doctor can order to help you and your care team know how well you are progressing through treatment. 


This material was adapted from the resource: "Endometrial Cancer: Your Guide" from Click here to download the full document.